well, if you're starting someone from chicago/dallas NOT named Witten, you might be in trouble anyway.
As for Det/Indy, should be an interesting game- Detroit is always up for the t-giving game, and it seems they take pride in their reputation as giant-killers on Thanksgiving Day. But you know Peyton is gonna get his TDs. I'd be comfortable starting most anyone you would normally start in that game, with the exception of Harrington, who has only looked poorer and poorer in recent games, Jones (Jones who?) and both defenses. ROY is a nice start I think. As usual, James is a stud, Peyton is on everyone's Christmas wish list, and the plethora of WRs/TEs all have the usual chance at the 5 TDs to be thankful for each week. Any of them are nice plays against a Detroit D that is ok and will probably play inspired ball, but doesn't have the talent to be spectacular. With no real shut-down corner (Jimmy Smith and Keyshawn Johnson have both had very nice games against this D recently), Harrison will get his chances, especially if Wayne's last week convinces Detroit to limit the double teams on Harrison. Wayne, Stokely and the TEs will get their shots (though Stokely was just plain missing yesterday...).
So yeah, play the usual guys- Detroit will play Indy tough, but that offense is too much for Detroit's D. Edge might be in for a bit of a downer after last week's high (though the 4th quarter rest certainly helped), but not enough of one to not start him.