I'm going to start off-topic first...I would think that the winner of a league should draft last if orders had
to be given out by last year's placement just like any draft is done. It can be a good thing to be first though. I'd rather choose the position where I want to draft if I won a league. I know...not your question!
You should never have a set strategy going into any draft no matter where you are picking. It's all about best player available whether you're first, middle, or last. I personally think the first 6-7 choices of every draft should be a RB because of the scarcity of "studly" ones that show up every week. After that, your draft goes by what you need and who everyone else has taken.
Remember that you're getting two picks in a row (if it's serpentine), so if there aren't many left and the guy is a proven RB, go for him! But, if there is an elite WR and/or QB around in the 2nd round (probably not next year due to Manning/Culpepper scoring insanity) and the talent pool is still full of usable RB's that are somewhat proven (unlike the Barlows of the world), then you might want to make sure you shore up the WR/QB spot and get a serviceable RB in round 4.
It might be risky, but as long as the other two players you took back to back are consistent scorers that will end up netting you more points each week, it's worth it!