UPSIDE: If it's for a solid team that should never be close to getting shut out by anybody, then it's a good idea - you'll never get burned at both spots and some games could still be huge for both.
DOWNSIDE: All things being equal, you might want to avoid having too many guys missing the same week with a bye.
In general, you still just want to get the best player at each position, regardless of stuff like this. (That being said, I like having a 3rd WR or TE from the same team as my QB. TE scores, despite this supposed to be the year of the tight end, are still gravy.)
... in my opinion, of course - but that should always go without saying.
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