The worst loss has got to be the one when it is because you make a mistake. I lost in Week 16 because I didn't get the chance on Sunday morning to check to see if Drew Bennett was playing... he scored 12 points. Reggie Wayne was benched, and scored 2. I lost by 9. Of course, I had Moulds in there instead of J. Jones, who had a monster game. J. Jones has been very undependable lately, so I don't feel as bad about that one. I'd be interested to hear how others feel about that one. I'm thinking that the lesson I lshould learn from that one is that I should always play an RB over a WR.
I take solace in the fact that in my other league I won the Superbowl that same week thanks, mainly, to one of my WRs... Santana Moss. Go figure!