I awyas like a larger roster size myself.
I find w/ those settings, certain teams can ride 2 studs Like SA all the way to the bank.
If you use a larger roster size, Balance becomes the key.
I use qb, 2 wr, rb, 2w/r, te, w/t, k, D or IDPs
This allows for a balanced team to dominate, and also allows each owner to use more options at his line up.