every player in the nfl has some risk/reward factor. you never know who will be hurt or just have an off year.
what about alexander? madden curse?
just about every RB is high risk/high reward. mainly because most are picked in the first 3 rounds and these are guys who can make or break you season.
so i guess its best to focus on guys you can get good value from.
i think TO is a great example, so is Jamal Lewis.
i think you can get great value from Brees, Bledsoe, Favre, Brunell, and Warner, they are in positions to have great years but they could also easily be awful.
i think Joe Horn is another WR, Julius Jones another RB.
this is a tough topic in football cause you can basically name every player. i think this is usually more of a baseball thing.