What Flots said, but go in thinking about RB-WR with those first 2 picks, that way you have a solid foundation to build upon.
You should have a shot at either Rudi, Portis, FWP, or Caddy. Then WRs will fly off the board after you and I like the depth at RB this year enough to take a WR at 2.01. SSmith will probably be off the board, but you should be able to snag Fitz, CJ, Harrison or Holt at that spot. They won't be there when you pick next.