They were playing one of if not the worst run defense in the league. The Colts' O-Line is awesome as well. He will not keep this up, especially if the Colts lock up home field. Yes, he did run very well today and obviously has good talent. But I don't see him scoring 3-4 TD's a game considering he only had three going into this one. However, if he does start getting the bulk of the carries, I'm sure his yardage and usefulness as a fantasy back for the next few weeks will increase.
I am not liking having Wayne (and Vinatieri to a lesser extent) on my team for the fantasy playoffs. Any Colts starter is a scary play.