I was just reading through all the "not setting a lineup" threads, and I thought of something.
In one of my leagues, a few months ago, my only QB option was Bruce Gradkowski (playing in the 40 MPH wind @ the Meadowlands when the G-Men were playing well).
Would it have been acceptable to leave my QB spot empty if I believed my QB would get me negative points and hurt my team?
Or would this be somehow wrong, unethical, etc.?

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