As the commish the best way to do good in the league is rig the draft order so you get to pick 1st and get LT2

IMO the biggest difference between large and small leagues is how much the WW affects teams. In large leagues depth is hard to achieve, so key pickups off of waivers can really boost your team when you plug a guy into the starting lineup.
Along with this I would strategy I would draft players in the very late rounds that are high risk/high reward, but don't hold on to them to long b/c you have a feeling they will produce soon (I have done this before).