The first few rounds are basically the same, it's the middle and later rounds that change a lot.
Someone that is taken in middle of the 6th round for a 12 teamer (pick 66) is going in the middle 7th for a 10 teamer.
Someone taken in the middle of the 8th round for a 12 teamer (pick 91) is going at the beginning of the 10th round for a 10 teamer.
Someone taken in the middle of the 10th round for a 12 teamer (pick 115) is going at the middle of the 12th round for a 10 teamer.
The easy way to look at it is depth is easier to come by in a 10 team league, so don't worry about finding good depth earlier on in the draft and get some good starters first.
Thanks to deluxe_247 for sig, he is welcome to sail with the Captain too!
I will win all of the fantasy cafe games.....next year