We run the same setup with 2 RB, 3 WR, 1 QB, 1 FLEX (anything...even a flippin' kicker if you want to). The main reason why RB are so valuable and need to be drafted first is because there are so few good ones and you need to start 2 each week. With a FLEX, the league essentially becomes a 2 QB league, which IMO, makes QB just as valuable. I'd still go LT, AD, S-Jax, Westbrook, Addai with the first few picks, but after that I'm looking to snag Brady, Manning, Brees, Romo, etc...probably go QB/RB or RB/QB with your first two picks, then pick value after that. Nothing is set in stone, but a solid core is at least 2 QB and 2 RB in your first five picks.