I think if you have one WR projected higher than another you should always take them instead of worrying about which team they came from. I guess I can understand the concern as I guess the scenario of getting "owned" by a defense would cause both players to suffer. Furthermore, offensive players like the Colts highly depend on the health of Peyton Manning. But still, I think if you believe one guy is going to score more than another guy at the same position, you kind of have to take him.
Heck, I barely even look at bye weeks anymore as it's just not going to stop me from grabbing that great value player.