SF is going to turn the ball over, there is no question.
That said, I really don't like the line on this game. SF is a much improved team over last year and their mistakes and not talent level is what is going to be their downfall in this game. I don't think the Seattle offense will be strong enough for them to win by a TD+. IF anything, SF will give this game away to Seattle.
I do think the Seattle home crowd will pump up the defense and that they will be bringing regular pressure on O'Sullivan. I'd say there is a decent chance Seattle D comes up with a TD this week, considering the horrible spots on the field SF turned it over against Arizona. Seattle has quite a few playmakers on the D.
I'm going to play Seattle against St. Louis and then drop them for the best D on the waiver. Seattle is looking UGLY this season, they are down to WR #7 on the depth chart . And they gave up 30+ points to Buffalo and SF.