Every year I've played fantasy, I have drafted towards the very tail end of QBs taken. However this year, I made a trade in the off-season to pick up Brees because IMO he could have an even better year than last, which is pretty scary.
I'd keep Brees, Gore, and Wayne/White. Those WR are kinda a toss-up in my opinion, with both in pretty ideal situations. Welker is also a very valuable receiver in PPR. He may not get you a 150/2TD performance, but he'll get you 8 catches for 80 just about every week.
With all that said, I think you must look to trade some of those players. Either a 2 for 1, or trading a player for a draft pick. Someone in your league almost certainly will be interested in whichever receivers you decide to let go.