i think since you have the #1 rookie pick you are freed up to take something besides RB at #5. you should get your choice of Knowshon or beanie Wells as your rookie pick and could be a nice pairing with AP. your #5 cant afford to be a bust, so i would rule out Brady, Westbrook, and LT at that spot. i think Brees or Fitzgerald would be a nice second pick, but thats too high for them so id try to trade down a few spots in exchange for moving up in the middle rounds. if you cant then id take best available RB-(maybe Sjax or Gore) at #5 and try to trade them early in the season for a WR1 and something else.
I think there's a dropoff after the top 4 RBs, so id try to move up a spot to get Turner, MJD or Forte, (pairing 2 of the top tier Rbs would be money in the bank) or move down a few spots to get Fitz, Brees, Moss,or AJ.