If you can score what you think is an extremely solid RB with that first pick, and then an elite stud WR falls to that 2.10 pick, I might take the gamble with Bush in that 3.3 pick, especially in 1 PPR scoring. If he is a bust, you have some pretty good studs to still carry your team in a combo like MJD/SS with the first two picks. If you win, you get a PPR monster and two very solid RB1-producing RBs. The way I see it, Bush is the kind of player this year that can produce a fantasy champion, or a mediocre team, assuming you finish the draft as if he is a big injury risk, and get a RB with two of the next three. You might want to try moving a little back in the third round via trade, and moving up in the fourth round to see if he is there, while you draft a guy like R Brown, Boldin etc. in the third round to make sure you have a solid enough team to take him in the early fourth if he falls that far, if you really want him. He might be too much of a risk to take in the early third.
Basically, you could have a core team of:
If Bush is healthy and as productive as he was early last year, that is a beasty team in PPR. If Bush fails again, it could be:
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Representin' the Cafe in the IBL league: 73-34, 15-8 in Championship Tier playoffs
Money league: 9-4, #1 seed one and done