Nice thought, but none of those guys you mentioned will be RB2s. The closest will be JStew, but the owner using him as a RB2 waited too long to grab another RB.
The problem you run into is that you are essentially drafting a team RB. Your opponent will have two productive RBs getting the majority of carries for their respective teams. Unless your team runs the ball twice the number of times as any other team, it won't work out for you on a regular basis.
I'm all for getting the handcuff of those good running teams, but don't depend on the handcuff as your RB2. I don't see how that will work for you unless you are getting a McGahee/Rice later in the draft because you took Brees, Moss, and Jennings in the first 3 rounds. Maybe then it wouldn't hurt, but you'd better take 5 RBs in a row anyway if that is your strategy.
Basically, I wouldn't intentionally do this. I don't see the benefit, and you'll probably end up reaching for one of them just to execute your strategy.