I don't think schedule is totally meaningless: I would start Willis McGahee if he were playing the Lions and Broncos every week!
Having said that, I think the points made above a right on the money. I love Chris Johnson, but J Stewart has been nursing injuries since, I believe, his last year in college. Hasn't played much at all this preseason. D Williams on the other hand has been on fire this preseason. For what its worth, the Panthers coaching staff has stated that Williams will "get the bulk of the carries."
Definitely go with Williams.
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