Based solely on match ups I would initially say Felix Jones. But since these are relatively boom or bust type players that are hard to predict a consistent score from I would go with Jackson. More opportunities + being the deep threat, for now anyways.
My vote: Desean Jackson
Tip: Please put the match ups in your post to make it easier to respond to...
Help with mine:viewtopic.php?t=444234
RBs- Forte, Sproles, Martin, K Smith, Ronnie Brown
WRs- Welker, D-Jax, Britt, Mike Williams, Lance Moore, LaFell
K- Jason Hanson
Def- Buf D