Tough call. I see the Bills wanting to play Lynch, but if Jackson has a strong outing again this week it's gonna be tough to sit him.
It really depends on your needs. If you have a glaring hole at QB or WR, trade Jackson while he's hot. Even if Lynch shares carries you still have strong depth ahead of him on your roster.
I'm afraid it you wait you'll lose value on one or both of them. But I'd only trade if you need help elsewhere.
Good luck, and please see mine:viewtopic.php?t=449803