I'm going to go out on a limb and say grant and holmes. I would have a hard time sitting someone who is getting 18-19 carries a game in grant even if it is MIN defense he's going against. Hester has a great matchup but I think CHI will get forte going early and often. With Parker out, Rothlisberger might be playing from behind and will have to rely on his big play wr holmes to catch up. Don't be scared by his 1 rec outting last week, he is still the 4th most targeted wr in the league.
1QB, 2RB, 2WR, 1 WR/TE, K, DEF
Standard 12-Man Auction League
QB - C. Newton, J. Flacco
RB - R. Rice, M. Jones-Drew, M. Tolbert, C.J. Spiller, D. Karim
WR - L. Fitzgerald, W. Welker, J. Graham, L. Moore
K - S. Gostkowski
DEF - Jets, Titans