I would start Welker and Sims-Walker. Its close between Sims-Walker and Moss, the only difference being that I trust JAX offense more than the WAS offense. Steve Smith is a bencher this week... he'll be covered by Asomugha all day against OAK, the Giants will be running more than passing, and the times they do pass will be to the opposite side of the field from Asomugha.
For RBs, if Westbrook is back I'd start him and Glen Coffee. Coffee may have disappointed this week, but theyll likely still give him 20-25 touches next week, which will be far more opportunities than Moreno, and you just cant trust Portis at this point.