Colston is a lock for me, then I'd probably go Holmes and Nicks. The Giants seem to be using Nicks more and more every week and I always like WR against Arizona. There is always a chance of a shootout. Holmes may be a top reciever by years end, and I wouldn't want to look back at think I benched him for Johnny Knox. Sidney Rice is your questionable bencher here. If you must bench one of those three I named for Rice, make it Nicks. But I'd go Colston, Holmes, and Nicks.