As the above post says, it's ultimately your call. However, I own Wayne myself, and will be starting him this week. He's Peyton's favorite target, and the Colts still seem to like to pass even when they're up by a good margin. True, if his groin is still tweaked, they may sit him should the Colts jump out to a huge lead. But I have a feeling he'll likely grab a TD or two before that happens.
(0.5 PPR, 12-team league)
QB: Vick, RG3
RB: McFadden, Matthews, K. Smith, R. Williams, M. Goodson
WR: Nicks, S. Smith, Britt, LaFell
TE: Hernandez, Pitta
DEF: Spot start (Cin in wk4)