I agree with the previous post. You gotta think that NO will get out to a big lead and TB will have to throw a lot...good potential for interceptions. If the Cards still had Warner, then you might make a similar case. But Leinart's not such a sure thing to post big numbers and, as posted above, STL hasn't looked bad so far.
If I had this choice, I think I'd choose NO.
12 team, H2H, Standard Scoring (Starters in bold)
QB: P. Manning, Luck
WR: Julio Jones, Welker, Alexander, Hilton, Shorts
RB: Rice, Wilson, BJGE, LeShoure
DEF: DET, SD