I'd go with Chambers for the safe bet. Meacham had two TDs last week, but only caught two passes. Meacham has the higher risk/reward in my book.
[12 Team league. Starts 1QB,3WR,2RB,1TE,2WR/RB,1K,1Def
QB: Big Ben, Cutler
RB: Rice, Best, R Williams, Woodhead, J Forsett, McGahee
WR: R Wayne, D Jackson, S Smith (NY), Gaffney, S Smith (CAR)