the way I see it, their are 9 first round players.
Johnson, Peterson, Gore,Jones-Drew, Rice, A.Johnson, Jackson, Moss, Turner
After that, (even including Johnson/Moss), it's a toss up to what people like. Some people will tell you Fitzgerald(or Johnson/Moss, whoever is available) would be the best pick here. Personally, I'm afraid of Fitz. If Moss or Johnson happen to fall to you at 10, nab one of them.
As for you're 2nd pick...I would go with Mathews. I think he's going to have a monster season in San Diego. A RB is the product of his O-Line. Mathews may not produce huge numbers in the first 2 or 3 weeks, but I think he could finish as a top 5 back by seasons end.
If you're wary about drafting a rookie with you're first pick, which I'm sure a lot of people are, you can go with a safe bet by pairing up with a QB. You can't go wrong with Rodgers, Brees, or Manning. But again, like me, some people don't like drafting a QB early.
Another 'risky" option you can go with is Jamaal Charles. I think hes going to be a stud this year. He already did it on Kansas City, so you can't de-value him because he's on a bad team. He's already produced. His numbers at the seasons end were unbelievable, you just have to worry about T.Jones taking away some goal line touches. But Ray Rice doesn't get goal line touches either, and hes a top 5 back, so in my opinion you don't have much to worry about with Charles.
Of the people who are potentially available here, this is my list (in order)
Moss, A.Johnson(if both are there, you're gold), Mathews, Charles, QB(Rodgers, Brees, Manning)
I'm not a big fan of DeAngelo with his contract expiring and Stewart splitting carries with him. Not a fan of Fitz with his injury and the Cardinals changing their offense. Wayne could be an option, you know you're going to get 1200/10 from him. If you like hook ups, maybe pair him up with Manning. Other options are Austin, Marshall, C.Johnson, or Mendenhall.
But anyway, you have my two cents. i'd go with what I listed earlier in that order. If by some miracle you can pair up Moss and A.Johnson, you'll be in solid shape. Look for something like Jacbos/R.Brown/or a QB after you draft your 2 WRs, and you got a solid team.
The Fantasy King!