First Week D/ST to play (WHIR)

[Dr.Bloodmoney]

12man ESPN league. I drafted NO in the second to last round but realize don't like the first matchup against Min. I do like the looks of the Cards @ StL or SD @ KC. Anyone have some thoughts? i usually enjoy picking Ds off the wire so Why hold on to NO if I don't like the matchup. Am I missing anything obvious about these matchups?

[B3N1ZJAM1N]

I don't think you're missing anything. I feel the best way to go through a season defensive wise is to go with the best defense available.

[curtk]

Agreed. And SD has some great matchups in the early weeks...you can likely use them four of the first five weeks, at least. I'd scoop them up if they're available...(I did in my league!)

Week 1: @ KC
Week 2: JAC
Week 3: @ SEA
Week 4: ARI
Week 5: @ OAK