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I don't remember Forsett's matchup, but while Caddy has a good matchup against CLE, I think I'd give the nod to Spiller for his upside. Even though he goes against MIA, I think he'll get enough opportunities to justify the start.
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12 team, H2H, Standard Scoring (Starters in bold)
QB: P. Manning, Luck
WR: Julio Jones, Welker, Alexander, Hilton, Shorts
RB: Rice, Wilson, BJGE, LeShoure
DEF: DET, SD