Tough one. Unless you know you can get a back-up RB, I would have a hard time doing this one. If you think you can get another RB, then do it.
12 Team League. We start 2 QBs and get .5 PPR, otherwise standard scoring
QBs: Stafford, Fitzpatrick, Collins
RBs: Charles, Mendenhall, Best, Starks, Carter, Karim
WRs: D. Jackson, Marshall, S. Smith, Green,
TE: Hernandez, Cook