This is always a crap shoot giving advice before the season started so using the normal defensive trends and offensive tendancies can't be used so at first I was thinking Harrison and one of the others. After looking further for entertainment reasons(and because all 3 are close) I would play Charles so I can follow him Monday night , and Spiller since he is playing at home. Harrison could be the best play since he might have the least competition, but he is on the road. Good luck
QB's Brady, Alex Smith
RB's MJD, Jacobs, Addai, Reggie Bush
WR's Crabtree, Mike Wallace, Harvin, Garcon, V. Jackson, Knox
TE's Gates
K's Akers,
D 49ers