Given the match-up, I still like Wells more than Reggie...he'll likely get more of an even split usage-wise (perhaps with the carries split in his favor), and NO just has so many other weapons.
(0.5 PPR, 12-team league)
QB: Vick, RG3
RB: McFadden, Matthews, K. Smith, R. Williams, M. Goodson
WR: Nicks, S. Smith, Britt, LaFell
TE: Hernandez, Pitta
DEF: Spot start (Cin in wk4)