I would definitely go with A. Bradshaw, he will be the feature back for the Giants, while T. Hightower will be splitting carries with B. Wells. HOWEVER, if B. Wells happens to not be playing, then start T. Hightower. Make sure you stay up to date with the news.
For WR, I would stick with M. Crabtree.viewtopic.php?p=3222607#p3222607