Yes I'd drop the 49ers D to get the Panthers for the week 2 start. Those other two matchups are terrible. No big deal if somebody snatches up the 49ers Defense (it won't happen anyway).
12 team H2H league, standard scoring, no PPR.
QB: Cutler, Kitna
RB: All Day AP, CJ2K, F.Jax, R.Brown, S. Greene, Dixon
WR: G. Jennings, Roy Williams, M. Williams (sea)
TE: J. Tamme
K: Hartley, Carpenter