It would help a lot if you posted their individual matchups.
Since you're stronger at WR than RB, I'd pick three WRs and two RBs. Without knowing all the matchups, I'd say:
RB: MJD and Thomas (but I really like BJax and wouldn't be at all surprised if he outscores Thomas this week)
WR: Fitz, Marshall, and 85.
Help with mine?viewtopic.php?f=19&t=473574
12 team, H2H, Standard Scoring (Starters in bold)
QB: P. Manning, Luck
WR: Julio Jones, Welker, Alexander, Hilton, Shorts
RB: Rice, Wilson, BJGE, LeShoure
DEF: DET, SD