If we're going strictly by matchups, you have to play Jackson and McFadden this week. They both play inferior run defenses. But then again Ryan Matthews was the guy you drafted early and he doesn't necessarily have a bad matchup either. But also consider the fact that he was benched the entire 4th quarter vs the Chiefs in favor of Sproles and that other big back whos name is escaping me at the moment. That's not a good sign. And I have Matthews on my team too and would love to be biased and say "Start Matthews all the way", but you gotta play the matchups..
I have a similar dilemma if you can help me out... http://www.fantasyfootballcafe.com/forums/viewtopic.php?t=473841
QB - Drew Brees, Tony Romo
RB - Adrian Peterson, Trent Richardson, Alfred Morris, Jacquizz Rodgers
WR - Brandon Marshall, Julio Jones, Vincent Jackson, Anquan Boldin, Golden Tate
TE - Heath Miller
DEF - Rotating
K - Justin Tucker