I'd go with Best. I think Peyton will be airing it out against the Giants, whereas the Lions will be relying heavily on their run game to get them through this matchup. Best will see far more touches.
12 team H2H league, standard scoring, no PPR.
QB: Cutler, Kitna
RB: All Day AP, CJ2K, F.Jax, R.Brown, S. Greene, Dixon
WR: G. Jennings, Roy Williams, M. Williams (sea)
TE: J. Tamme
K: Hartley, Carpenter