I wouldn't. Mathews injury doesn't look too serious, but the big issue is Tolbert's game. He scored a TD before Mathews was out, and then again afterwards. Even if Mathews plays, Tolbert could steal TDs from him. Bal's pass game doesn't look overly powerful yet either, so just hoping Boldin pans out for Forte and Johnson? I would not do this.
10 Team; 1QB/2RB/2WR/1Flex/1K/1D; Standard; Non-ppr
QB: Vick, Orton
RB: Forte, Bradshaw, Addai, Lynch
WR: D.Jackson, S.Smith(Car), Garcon, Bess, Blair White
D: Phi, Ari