This is a tough call, as I think both will have good games. Given the situation in SD though, I think I'd go with Bradshaw. Both have pretty good matchups, the only thing I'd worry about with Bradshaw is the Texans jumping out to an early lead and Bradshaw not getting as many carries as he would otherwise. I think Mathews will be the starter and get the bulk of the carries, I dont see Tolbert vulturing goalline stuff, as Norv Turner tends to stick with one back, and has stated that Ryan is his guy. Bradshaw, I think, is the safer play, I think both will do well, but Bradshaw seems more likely to do well.