League 1: Agree with Blount. He's got the better match up with the Redskins and should have decent production.
League 2: I like Jackson here, but it is iffy. He didn't produce much against the Vikings, but the Vikings have been good at stopping the run and the Bills really didn't produce well at all. This week should be much different if the Bills show up to play.
Defense is a bit of a toss up, like you said. I'd probably go with the Giants. They both have good match ups but the Giants are the better D imo.
Oh, and you're listing the team the player is on for a lot of these, not his match up