Hillis you definitely have to play. He's just too consistent regardless of opponent or situation (playing from behind, huge lead, doesn't matter)
Moreno I think you have to play too. He's been looking like a man on fire, and when the running back's coach all of a sudden becomes the head coach... I think you're looking at some serious touches for him. Pair those with the fact that he's against Arizona, and I think he's looking like a top 5 RB this week.
Which leaves Rice and Charles. Rice is great obviously, and he's got the hands to be involved in the passing game too, which makes him safe against a Houston team that's going to have to go for broke on offense to stay competitive. I think he's going to put up some good numbers on Monday.
Charles is always a tough one, because he's obviously capable of amazing numbers, given his potential to beat the secondary if he gets through. He's a home run hitter, but he's your risky option. I think that he COULD potentially outscore Rice, but the chance isn't worth the risk.
In your position, as hard as it is to sit a guy like Jamaal Charles, I think I'd go Hillis, Moreno, Rice for this week.