PPR or not?
If so, then I think I would go Steven Jackson due to his matchup, and the fact that I think they'll be spending a lot of time killing the clock if Cassell doesn't play. Charles scares me since they should be behind a lot of the game and he didn't do much last weekend without him.
If it isn't PPR, then I would consider Blount.
Of course this all changes if Cassell can play... then I would pick Charles.
Take a look at mine?viewtopic.php?f=19&t=488294
12 team, 0.5 PPR, 10yds rush/rec, 25 pass yd, 6 point TDs
1QB, 2RB, 2WR, 1TE, 1WR/RB/TE, 1K, 1DEF/ST
QB: Vick, Freeman
WR: Marshall, Gaffney, Amendola, N.Washington, VJax
RB: Peterson, Foster, Charles, Portis