I try to avoid it when bulding a team. As the year progresses and I have a weak team then maybe I try to set that up for some big weeks, but then you also have to be prepared to get spanked when the team is shutout.
What I strive for is balance and consistancy. If one team is shutdown you don't want that to effect more than one player, especially a QB and WR1 or RB1.
QB: BREES, Cutler
RB: TURNER, MCGAHEE, R. JENNINGS, Leshoure, D. Williams, Hillman, Hunter, Dwyer
WR: CRUZ, GARCON, Amendola, Edwards, D. Baldwin