Just like sometimes it can be tough to gauge value in smaller leagues, the same is true for deeper ones.
You have decent top options at wide receiver and running back. I agree that you can lose Blaine Gabbert. He has decent long term value but not a lot as far as 2011 is concerned. You are far from doomed. If a couple things break your way, like Ryan Williams getting to shoulder a large workload, James Starks getting goaline work, Maclin not experiencing any negative effects from his missed time due to sickness, Moeaki or Pettigrew being able to break out, and Jennings being able to retain a high target load, your team will be as strong as anyone's.
Good luck in 2011