Who should I start week one? I'm leaning toward starting Stafford simly because the guy I'm playing's best player is Calvin Johnson. Starting Stafford would wash out any points Johnson scored.
I have the same two guys as you do, in a league where we get 4 points for passing TDs and 6 for rushing, and I'm still starting Stafford. If he stays healthy he's easily got the potential to put up top-5 QB points this year.
I don't agree with the reasoning, as you're not actually washing out his points, but I agree with the choice so it's a moot point. Every week, at every position, you should start the guy who will get you the most points - never worry about "doubling" points or "canceling" points for your or your opponent. Good luck this week
I'm not sure what the matchups are, but I'd start Stafford.
He's clearly the better QB and he leads the better offense. Definitely start him while he's healthy, and hope he doesn't get banged up in the first half...