I have Wayne on my team also. I am definitely starting him this week.
The reason....Houston is a high powered offense. They are are going to score a lot of points. The Colts can't run the ball. The Colts will have no choice but to throw it a lot to try to stay in the game. Last year Houston was horrible against the pass. They have upgraded their Corners this year, but until they show me different I am considering them suspect.
If the Colts were playing a lower scoring team, I may downgrade Wayne a little. But again Houston, I think Wayne will have a big game.
10 team, PPR, 1 qb 1rb, 2wr, 2flex (rb/wr/te), 1k, 1dst
QB: Stafford, E. Manning
RB: Peterson, Blount, Hightower, Starks, Tate, Tolbert
WR: Nicks, Wayne, Bowe, S. Johnson, M. Thomas