Absolutely, the opposing team can influence what defense you decide to play.
Your defense earns points by forcing turnovers (INTs, Fumbles), Sacks, Safeties, Blocked Punts/Kicks, scoring Defensive TDs and in some leagues holding the opposing offense to x amount of points and/or yards. There are other scoring options your league might use but this is just a few.
With that said your looking at a very tough choice...
NO @ GB
Det @ TB
Green Bay and Detroit are no slouch on offense, both will put up points, if I had my pick I'm going with Tampa Bay. They are the home team and Detroit has a young team that will turn the ball over. I am a Packers fan so take my opinion fwiw.