This would not even be a question with a healthy Peyton on board. But life without Peyton forces the Colts to be a more run-oriented offense, IMO.
If you play in a PPR league, I would lean towards Wayne because he should still command and lead targets for Indy. If it is a TD-heavy league, then I think Britt is the better play this week with a better fantasy matchup against the Jags.
14tm. PPR+IDP+return-yds. league
TE-Finley K & IDP-[streaming]