Removing the bias that I am a Redskins fan
Hightower is a top play for this week, and he is the only Redskins back I find worth owning (unless you judge Helu as a sleeper pick). He may lose a large majority of the goal-line touches, but he'll get a signficant amount of carries, especially since the Redskins are going into the season with Grossman/Beck.
10 team H2H league, standard scoring [NFL.com]
QB: A. Rogers
RB: MJD, S. Jax, J. Starks, D. Murray, M. Bush
WR: M. Wallace, B. Marshall, P. Harvin, M. Colston, L. Robinson
TE: O. Daniels, J. Gresham
K: Sebastian Janikowski